细胞衰老、癌症与机体衰老：范式转变
Cellular senescence, cancer, and organismal aging: a paradigm shift.
作者信息
Lim Chang-Su
机构信息
Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.
出版信息
Biochem Biophys Res Commun. 2006 May 26;344(1):1-2. doi: 10.1016/j.bbrc.2006.03.161. Epub 2006 Apr 3.
PMID:16616892
Abstract
Cellular senescence is an anti-cancer mechanism and may contribute to organismal aging. A change in paradigm has been proposed that cellular senescence may reduce cancer mortality rather than promote it late in life, and thus positively contributes to longevity in organisms with renewable tissues as a common mechanism across the species.
摘要
细胞衰老 是一种抗癌机制，可能会导致机体衰老。有人提出了一种范式转变，即细胞衰老可能会降低癌症死亡率，而不是在生命后期促进癌症死亡率，因此作为一种跨物种的共同机制，对具有可再生组织的生物体的长寿有积极贡献。
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