Degirmenci Ufuk, Lei Sun
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore; Programme in Cardiovascular and Metabolic Disorders, Duke-NUS, Singapore.
Front Endocrinol (Lausanne). 2016 Dec 6;7:151. doi: 10.3389/fendo.2016.00151. eCollection 2016.
Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.
衰老 是一种普遍、内在且随时间推移的生物衰退过程，与复杂的细胞过程相关，包括细胞衰老、端粒缩短、干细胞耗竭、线粒体功能障碍以及代谢失调。细胞衰老被认为是机体水平衰老的核心过程之一。了解衰老背后的分子机制有助于开发针对衰老及与年龄相关疾病的潜在治疗方法。最近，长链非编码RNA（lncRNA）的发现为一个可干预细胞衰老的新型调控层面提供了见解。越来越多的证据表明，靶向lncRNAs可能会影响衰老途径。在本综述中，我们将聚焦于参与调控细胞衰老机制途径的lncRNAs。
