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Orientation of beta-barrel proteins OmpA and FhuA in lipid membranes. Chain length dependence from infrared dichroism.β-桶状蛋白OmpA和FhuA在脂质膜中的取向。红外二色性的链长依赖性。
Biochemistry. 2005 Mar 8;44(9):3515-23. doi: 10.1021/bi047603y.
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Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR.通过2H固态核磁共振测定的跨膜模型肽在定向和非定向脂质双层中的倾斜角度。
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Elastic coupling of integral membrane protein stability to lipid bilayer forces.整合膜蛋白稳定性与脂质双分子层力的弹性耦合。
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Secondary and tertiary structure formation of the beta-barrel membrane protein OmpA is synchronized and depends on membrane thickness.β-桶状膜蛋白OmpA的二级和三级结构形成是同步的，并且取决于膜的厚度。
J Mol Biol. 2002 Nov 22;324(2):319-30. doi: 10.1016/s0022-2836(02)01071-9.
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Structural transitions in short-chain lipid assemblies studied by (31)P-NMR spectroscopy.通过³¹P核磁共振光谱研究短链脂质聚集体中的结构转变。
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Structure of outer membrane protein A transmembrane domain by NMR spectroscopy.利用核磁共振光谱法测定外膜蛋白A跨膜结构域的结构。
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Structure of lipid bilayers.脂质双层的结构
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Effect of chain length and unsaturation on elasticity of lipid bilayers.链长和不饱和度对脂质双层弹性的影响。
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Outer membrane protein A of Escherichia coli inserts and folds into lipid bilayers by a concerted mechanism.大肠杆菌的外膜蛋白A通过协同机制插入脂质双层并折叠。
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Entropy-driven tension and bending elasticity in condensed-fluid membranes.凝聚流体膜中的熵驱动张力和弯曲弹性。
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膜弹性涨落与β-桶状蛋白的插入和倾斜

Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins.

作者信息

Marsh Derek, Shanmugavadivu Baladhandapani, Kleinschmidt Jörg H

机构信息

Max-Planck-Institut für biophysikalische Chemie, Abteilung Spektroskopie, Göttingen, Germany.

出版信息

Biophys J. 2006 Jul 1;91(1):227-32. doi: 10.1529/biophysj.105.079004. Epub 2006 Apr 14.

DOI:10.1529/biophysj.105.079004
PMID:16617078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1479067/
Abstract

Folding of porin-like beta-barrel outer membrane proteins can be achieved in the presence of phospholipid vesicles, and takes place concurrently with incorporation into the membrane. The pronounced dependence found for the insertion of the protein OmpA on membrane thickness (Kleinschmidt, J. H., and L. K. Tamm. 2002. J. Mol. Biol. 324:319-330) is analyzed in terms of the effects of out-of-plane elastic fluctuations on the area dilation modulus (Evans, E., and W. Rawicz. 1990. Phys. Rev. Lett. 64:2094-2097). For unstrained large unilamellar vesicles, the elastic free energy for membrane insertion is predicted to depend on the fourth power of the membrane thickness. The influence of thermally induced bending fluctuations on the effective tilt of the OmpA beta-barrel in disaturated phosphatidylcholine membranes of different thicknesses (Ramakrishnan, M., J. Qu, C. L. Pocanschi, J. H. Kleinschmidt, and D. Marsh. 2005. Biochemistry. 44:3515-3523) is also considered. A contribution to the orientational order parameter that scales as the inverse second power of the membrane thickness is predicted.

摘要

在磷脂囊泡存在的情况下，孔蛋白样β桶外膜蛋白可以实现折叠，并且在整合到膜中的同时发生。根据平面外弹性涨落对面积膨胀模量的影响（埃文斯，E.，和W. 拉维茨。1990年。《物理评论快报》64:2094 - 2097），分析了蛋白质OmpA插入对膜厚度的显著依赖性（克莱因施密特，J. H.，和L. K. 塔姆。2002年。《分子生物学杂志》324:319 - 330）。对于未受应变的大单层囊泡，预测膜插入的弹性自由能取决于膜厚度的四次方。还考虑了热诱导弯曲涨落对不同厚度的二饱和磷脂酰胆碱膜中OmpAβ桶有效倾斜的影响（拉马克里什南，M.，J. 曲，C. L. 波坎斯基，J. H. 克莱因施密特，和D. 马什。2005年。《生物化学》44:3515 - 3523）。预测了对取向序参量的贡献，该贡献与膜厚度的倒数二次方成比例。