Dyall-Smith D, Trowell H, Dyall-Smith M L
Department of Dermatology, Monash Medical Centre, Clayton, Victoria, Australia.
Int J Dermatol. 1991 Nov;30(11):785-9. doi: 10.1111/j.1365-4362.1991.tb04787.x.
Warts and cutaneous squamous cell carcinomas are common complications of immunosuppression. We studied a total of 189 renal transplant recipients clinically for such lesions. The incidence of warts increased steadily after transplant, such that of patients transplanted for more than 5 years, 92% were found to have warts and 65% had more than five warts each. DNA extracted from scrapings of their warts showed they carried the same human papillomavirus types as the general population, and not the unique set found on patients with epidermodysplasia verruciformis (who share with transplant recipients an increased incidence of warts and squamous cell carcinomas).
疣和皮肤鳞状细胞癌是免疫抑制的常见并发症。我们对总共189名肾移植受者进行了此类病变的临床研究。移植后疣的发病率稳步上升，以至于在移植超过5年的患者中，发现92%有疣，且65%的患者每人有超过5个疣。从他们疣的刮屑中提取的DNA显示，他们携带的人乳头瘤病毒类型与普通人群相同，而非疣状表皮发育不良患者（与移植受者一样疣和鳞状细胞癌发病率增加）所特有的类型。
