Das Bibhuti B, Anton Kristin, Soares Nelia, Riojas Susan, Mcdermott Jodi, Knox Leah, Daneman Susan, Puente Bao N
Joe DiMaggio Children's Hospital Heart Institute, Memorial Health Care, Hollywood, FL 33021, USA.
Children's Health Heart Institute, Dallas, Texas 75235, USA.
Med Sci (Basel). 2018 Apr 8;6(2):30. doi: 10.3390/medsci6020030.
: Immunosuppressed individuals are at particularly increased risk for human papilloma virus-related infections. The primary objective of our study is to determine if there are any adverse effects associated with high-dose cimetidine treatment. A secondary objective is to report our experience with cimetidine in the treatment of cutaneous warts in pediatric heart transplant recipients. : This was a retrospective observational study. A total of 8 pediatric heart transplant recipients diagnosed with multiple recalcitrant warts were the subject of the study. All patients were treated with cimetidine (30-40 mg/kg/day) in two divided doses for 3 to 6 month durations. All patients had complete resolution of their lesions except 1 patient who had no clinical improvement. Of these 8 patients, one had recurrence of warts at one year follow-up, which resolved with restarting cimetidine therapy. One patient who had only 3 months of cimetidine therapy had immediate relapse after cimetidine was stopped. None of them had significant change in their tacrolimus trough, serum creatinine, and alanine transaminase levels. No adverse events were reported except one patient experienced mild gynecomastia. : Cimetidine can be a safe and alternative treatment option for multiple warts in pediatric heart transplant recipients.
免疫抑制个体感染人乳头瘤病毒相关感染的风险尤其增加。我们研究的主要目的是确定高剂量西咪替丁治疗是否存在任何不良反应。次要目的是报告我们使用西咪替丁治疗小儿心脏移植受者皮肤疣的经验。
这是一项回顾性观察研究。共有8名被诊断患有多发性顽固性疣的小儿心脏移植受者参与了该研究。所有患者均接受西咪替丁治疗（30 - 40mg/kg/天），分两次给药，持续3至6个月。除1例患者临床症状无改善外，所有患者的皮损均完全消退。在这8例患者中，1例在一年随访时疣复发，重新开始西咪替丁治疗后消退。1例仅接受3个月西咪替丁治疗的患者在停药后立即复发。他们的他克莫司谷浓度、血清肌酐和丙氨酸转氨酶水平均无显著变化。除1例患者出现轻度乳腺增生外，未报告不良事件。
西咪替丁对于小儿心脏移植受者的多发性疣可能是一种安全的替代治疗选择。
