Leigh I M, Glover M T
Department of Dermatology, Royal London Hospital Trust, UK.
Recent Results Cancer Res. 1995;139:69-86. doi: 10.1007/978-3-642-78771-3_6.
Non-melanoma skin cancer (NMSC) is increasingly recognised as a complication of long-term immunosuppression and has been particularly studied in renal transplant recipients (RTR). A population study of renal transplant recipients has been performed with analysis of those features contributing to a high rate of detection of NMSC, such that 40% patients with fair skin have NMSC 5 years after transplantation. 90% of the total patient population have warts 5 years after transplantation, many being atypical and in sun-exposed sites. Therefore, contributory factors in these patients include not only the global immunosuppression, ultraviolet radiation (UVR)-induced mutagenesis and photoimmunosuppression, but also the widespread presence of human papillomavirus (HPV) infection, including the unusual epidermodysplasia verruciformis (EV)-associated cutaneous oncogenic HPV.
非黑色素瘤皮肤癌（NMSC）越来越被认为是长期免疫抑制的一种并发症，并且在肾移植受者（RTR）中得到了特别研究。已经对肾移植受者进行了一项群体研究，分析了那些导致NMSC高检出率的特征，结果显示40%皮肤白皙的患者在移植后5年患有NMSC。90%的患者群体在移植后5年出现疣，其中许多为非典型疣且位于阳光暴露部位。因此，这些患者的促成因素不仅包括全身性免疫抑制、紫外线辐射（UVR）诱导的诱变和光免疫抑制，还包括人乳头瘤病毒（HPV）感染的广泛存在，包括与疣状表皮发育异常（EV）相关的罕见皮肤致癌性HPV。
