输血相关急性肺损伤的双事件模型
The two-event model of transfusion-related acute lung injury.
作者信息
Silliman Christopher C
机构信息
Bonfils Blood Center and Departments of Pediatrics and Surgery, University of Colorado School of Medicine, Denver, CO, USA.
出版信息
Crit Care Med. 2006 May;34(5 Suppl):S124-31. doi: 10.1097/01.CCM.0000214292.62276.8E.
The objective of this review is to present the two-event model of transfusion-related acute lung injury (TRALI), a life-threatening complication of transfusions that has been the most common cause of transfusion-related death over the past 2 yrs in the United States. The two-event model of TRALI, which is identical to the pathogenesis of the acute respiratory distress syndrome (ARDS), is reviewed and contrasted to antibody-mediated TRALI. Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed.
本综述的目的是介绍输血相关急性肺损伤（TRALI）的双事件模型，TRALI是一种危及生命的输血并发症，在美国过去两年中一直是输血相关死亡的最常见原因。文中对与急性呼吸窘迫综合征（ARDS）发病机制相同的TRALI双事件模型进行了综述，并与抗体介导的TRALI进行了对比。同时讨论了体外和体内的实验室研究以及TRALI的人体研究。还讨论了避免患者接触可能导致TRALI的血液成分的方法。
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