缺血性心脏病高风险人群的晶状体早期老化加速：一项流行病学研究。
Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study.
作者信息
Kessel Line, Jørgensen Torben, Glümer Charlotte, Larsen Michael
机构信息
Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Denmark.
出版信息
BMC Ophthalmol. 2006 Apr 18;6:16. doi: 10.1186/1471-2415-6-16.
BACKGROUND
Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging.
METHODS
A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard software. Lens aging was quantified by lens fluorometry.
RESULTS
The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia.
CONCLUSION
The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.
背景
缺血性心脏病（IHD）是西方世界死亡率和发病率的最重要原因之一。人眼晶状体老化与心血管疾病之间存在关联。本研究旨在探讨是否可通过荧光光度法评估晶状体老化来估计缺血性心脏病的风险。
方法
共纳入421名受试者。使用Precard软件根据非眼部数据估计IHD风险。通过晶状体荧光测定法对晶状体老化进行量化。
结果
IHD风险与晶状体荧光团积累密切相关（p = 0.001）。IHD与晶状体老化之间的关系可归因于吸烟和血糖异常。
结论
与吸烟和糖尿病相关的缺血性心脏病风险可通过将眼晶状体老化作为全身组织损伤的生物标志物来估计。
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