Hunt R D, Daniel M D, Baggs R B, Blake B J, Silva D, DuBose D, Meléndez L V
J Natl Cancer Inst. 1975 Jun;54(6):1401-2. doi: 10.1093/jnci/54.6.1401.
Twenty-two of 39 rabbits inoculated with Herpesvirus saimiri developed malignant lymphoma and either died or were killed between 17 and 165 days after inoculation. No clinical signs were present in animals developing the disease before 46 days, but all other rabbits had a severe conjunctivitis, nasal discharge, and dyspnea resulting from a lymphocytic invasion of the ocular and nasal tissues. Four rabbits developed terminal leukemia. Pathologically, the disease resembled H. saimiri malignant lymphoma in nonhuman primates; there was extensive diffuse infiltration of most organs and tissues with either a lymphocytic or lymphoblastic infiltrate. Tumor nodules or masses seen in some forms of malignant lymphoma were not present. In contrast to nonhuman primates, all affected rabbits showed invasion of the skin of the nose and eyelids, conjunctiva, iris, ciliary body, and choroid. In 3 rabbits there was slight infiltration into the brain, not noted in nonhuman primates. The susceptibility of rabbits extended the host range of H. saimiri beyond the order Primates.
39只接种了猴疱疹病毒的兔子中有22只患上了恶性淋巴瘤，并在接种后17至165天内死亡或被处死。在46天前发病的动物没有出现临床症状，但所有其他兔子都因眼部和鼻部组织的淋巴细胞浸润而出现严重的结膜炎、鼻分泌物和呼吸困难。4只兔子发展为终末期白血病。病理上，该病与非人灵长类动物的猴疱疹病毒恶性淋巴瘤相似；大多数器官和组织有广泛的弥漫性浸润，浸润细胞为淋巴细胞或淋巴母细胞。在某些形式的恶性淋巴瘤中可见的肿瘤结节或肿块并不存在。与非人灵长类动物不同的是，所有患病兔子的鼻子、眼睑皮肤、结膜、虹膜、睫状体和脉络膜都有浸润。3只兔子的脑部有轻微浸润，这在非人灵长类动物中未观察到。兔子的易感性将猴疱疹病毒的宿主范围扩展到了灵长目以外。
