Unicomb Leanne E, Ferguson John, Stafford Russell J, Ashbolt Rosie, Kirk Martyn D, Becker Niels G, Patel Mahomed S, Gilbert Gwendolyn L, Valcanis Mary, Mickan Lance
OzFoodNet, Queensland Health, Archerfield, Queensland, Australia.
Clin Infect Dis. 2006 May 15;42(10):1368-74. doi: 10.1086/503426. Epub 2006 Apr 13.
Ciprofloxacin-resistant Campylobacter jejuni isolates obtained from infected patients in Australia have not been detected in studies of isolates from specific geographic areas. The Australian government has prohibited the use of fluoroquinolone in food-producing animals. To assess the impact of this policy, we have examined the antimicrobial susceptibility of isolates from 5 Australian states.
We conducted a period-prevalence survey of the susceptibility of C. jejuni isolates to 10 antimicrobial agents. C. jejuni isolates obtained from 585 patients from 5 Australian states (Queensland, South Australia, Tasmania, Victoria, and Western Australia) were identified by means of notifiable disease databases and were systematically selected from September 2001 to August 2002.
Among locally acquired infections, only 2% of isolates (range, 0%-8% in different states) were resistant to ciprofloxacin. The locally acquired isolates also exhibited resistance to sulfisoxazole (55%), ampicillin (46%), roxithromycin (38%), tetracycline (7%), nalidixic acid (6%), chloramphenicol (3%), erythromycin (3%), gentamicin (2%), and kanamycin (0.2%). Treatment with antimicrobial agents in the 4 weeks before onset was not associated with ciprofloxacin resistance.
The very low level of ciprofloxacin resistance in C. jejuni isolates likely reflects the success of Australia's policy of restricting use of fluoroquinolones in food-producing animals.
在针对特定地理区域分离菌株的研究中，尚未在澳大利亚从感染患者身上分离出的耐环丙沙星空肠弯曲菌菌株。澳大利亚政府已禁止在食用动物中使用氟喹诺酮类药物。为评估该政策的影响，我们检测了来自澳大利亚5个州的分离菌株的抗菌药物敏感性。
我们对空肠弯曲菌分离株对10种抗菌药物的敏感性进行了期间患病率调查。通过法定传染病数据库识别从澳大利亚5个州（昆士兰州、南澳大利亚州、塔斯马尼亚州、维多利亚州和西澳大利亚州）的585名患者身上获得的空肠弯曲菌分离株，并于2001年9月至2002年8月进行系统选择。
在本地获得的感染中，仅2%的分离株（不同州的范围为0%-8%）对环丙沙星耐药。本地获得的分离株还对磺胺异恶唑（55%）、氨苄西林（46%）、罗红霉素（38%）、四环素（7%）、萘啶酸（6%）、氯霉素（3%）、红霉素（3%）、庆大霉素（2%）和卡那霉素（0.2%）耐药。发病前4周内使用抗菌药物治疗与环丙沙星耐药无关。
空肠弯曲菌分离株中环丙沙星耐药水平极低，这可能反映了澳大利亚在食用动物中限制使用氟喹诺酮类药物政策的成功。
