Avato Pinarosa, Bucci Rossella, Tava Aldo, Vitali Cesare, Rosato Antonio, Bialy Zbigniew, Jurzysta Marian
Dipartimento Farmaco-Chimico, Via Orabona 4, Università, I-70125 Bari, Italy.
Phytother Res. 2006 Jun;20(6):454-7. doi: 10.1002/ptr.1876.
The antimicrobial activity of saponins from Medicago sativa, M. arborea and M. arabica against a selection of medically important yeasts, Gram-positive and -negative bacteria was investigated. Structure-activity growth inhibitory effects of related prosapogenins and sapogenins are also described. Increasing antibiotic activity was observed going from the saponin extracts to the sapogenin samples, suggesting that the sugar moiety is not important for the antimicrobial efficacy. Activity was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae. The observed antimicrobial properties of M. sativa and M. arborea were related to the content of medicagenic acid, while hederagenin seems to contribute to the bioactivity of M. arabica total sapogenins.
研究了紫花苜蓿、树苜蓿和阿拉伯苜蓿中皂苷对一些具有医学重要性的酵母、革兰氏阳性菌和革兰氏阴性菌的抗菌活性。还描述了相关原皂苷元和皂苷元的构效生长抑制作用。从皂苷提取物到皂苷元样品，观察到抗生素活性增加，这表明糖部分对抗菌功效并不重要。对革兰氏阳性菌（蜡样芽孢杆菌、枯草芽孢杆菌、金黄色葡萄球菌和粪肠球菌）的活性特别高，其中阿拉伯苜蓿表现出更广泛的作用谱。还观察到离散的抗真菌活性，主要针对酿酒酵母。紫花苜蓿和树苜蓿观察到的抗菌特性与苜蓿酸的含量有关，而常春藤皂苷元似乎有助于阿拉伯苜蓿总皂苷元的生物活性。
