Coleta Miguel, Batista Maria Teresa, Campos Maria Graça, Carvalho Rui, Cotrim Maria Dulce, Lima Thereza Christina M de, Cunha António Proença da
Center of Pharmaceutical Studies, Laboratory of Pharmacognosy, Universidade de Coimbra, 3000 Coimbra, Portugal.
Phytother Res. 2006 Dec;20(12):1067-73. doi: 10.1002/ptr.1997.
Passiflora edulis Sims together with several other plants of the genus Passiflora have been reported to possess anxiolytic properties. It has been suggested recently that flavonoids may be partly responsible for the neuropharmacological activity of these plants but there are still few data reporting the relation between the constituents of these plants and their activity. This work evaluated the anxiolytic/sedative activity of an aqueous extract of Passiflora edulis Sims and bioguided its fractionation using the elevated plus-maze model of anxiety and other complementary pharmacological tests. The aqueous extract presented an anxiolytic-like activity without any significant effect upon the motor activity whilst the total flavonoid fraction (TFF) presented an anxiolytic-like activity but compromised motor activity. Through fractionation of TFF it was possible to isolate and characterize luteolin-7-O-[2-rhamnosylglucoside] which showed an anxiolytic-like activity without compromising motor activity.
西番莲（Passiflora edulis Sims）以及西番莲属的其他几种植物已被报道具有抗焦虑特性。最近有人提出，黄酮类化合物可能部分负责这些植物的神经药理活性，但仍鲜有数据报道这些植物的成分与其活性之间的关系。本研究使用高架十字迷宫焦虑模型和其他补充药理学试验，评估了西番莲（Passiflora edulis Sims）水提取物的抗焦虑/镇静活性，并对其进行了生物导向分级分离。水提取物呈现出抗焦虑样活性，对运动活性无显著影响，而总黄酮部分（TFF）呈现出抗焦虑样活性，但损害了运动活性。通过对TFF进行分级分离，有可能分离并鉴定出木犀草素-7-O-[2-鼠李糖基葡萄糖苷]，其显示出抗焦虑样活性且不损害运动活性。
