Butler L D, Stieglitz T L
Dept. of Psychology, Stanford University, CA 94305-2130.
Schizophr Bull. 1993;19(3):449-54; discussion 455-9. doi: 10.1093/schbul/19.3.449.
This article discusses the literature on the possible role of viruses in the development of schizophrenia and outlines the evidence that compelled Crow and Done (1986) to reject a horizontal contagion hypothesis (e.g., sibling to sibling transmission). We posit a genetically determined age after which one becomes vulnerable to the illness, rather than a strict age of onset. We also propose an environmentally determined range of resistance to this susceptibility as an alternative conceptualization of the role of inheritance and of viral exposure in the etiology of the disease. The predictions derived from our new model fit the findings of Crow and Done and are consistent with the older literature of possible viral factors, thus reaffirming the horizontal contagion hypothesis.
本文讨论了关于病毒在精神分裂症发病过程中可能作用的文献，并概述了促使克罗和多恩（1986年）摒弃水平传播假说（例如，兄弟姐妹间传播）的证据。我们假定存在一个由基因决定的年龄，在这个年龄之后个体易患该疾病，而非严格的发病年龄。我们还提出了一个由环境决定的对这种易感性的抵抗范围，作为对遗传和病毒暴露在该疾病病因中作用的另一种概念化理解。从我们的新模型得出的预测符合克罗和多恩的研究结果，并与关于可能的病毒因素的早期文献一致，从而再次肯定了水平传播假说。
