转录后调节因子RsmA通过正向调节III型分泌系统，在铜绿假单胞菌与人气道上皮细胞的相互作用中发挥作用。
The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system.
作者信息
Mulcahy Heidi, O'Callaghan Julie, O'Grady Eoin P, Adams Claire, O'Gara Fergal
机构信息
BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
出版信息
Infect Immun. 2006 May;74(5):3012-5. doi: 10.1128/IAI.74.5.3012-3015.2006.
Abstract
Posttranscriptional regulation of certain virulence-related genes in Pseudomonas aeruginosa is brought about by RsmA, a small RNA-binding protein. During interaction with airway epithelial cells, RsmA promoted actin depolymerization, cytotoxicity, and anti-internalization of P. aeruginosa by positively regulating the virulence-associated type III secretion system.
摘要
铜绿假单胞菌中某些毒力相关基因的转录后调控是由一种小RNA结合蛋白RsmA实现的。在与气道上皮细胞相互作用的过程中，RsmA通过正向调控与毒力相关的III型分泌系统，促进了肌动蛋白解聚、细胞毒性以及铜绿假单胞菌的抗内化作用。
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