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转录后调节因子RsmA通过正向调节III型分泌系统，在铜绿假单胞菌与人气道上皮细胞的相互作用中发挥作用。

The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system.

作者信息

Mulcahy Heidi, O'Callaghan Julie, O'Grady Eoin P, Adams Claire, O'Gara Fergal

机构信息

BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.

出版信息

Infect Immun. 2006 May;74(5):3012-5. doi: 10.1128/IAI.74.5.3012-3015.2006.

DOI:10.1128/IAI.74.5.3012-3015.2006
PMID:16622241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1459696/
Abstract

Posttranscriptional regulation of certain virulence-related genes in Pseudomonas aeruginosa is brought about by RsmA, a small RNA-binding protein. During interaction with airway epithelial cells, RsmA promoted actin depolymerization, cytotoxicity, and anti-internalization of P. aeruginosa by positively regulating the virulence-associated type III secretion system.

摘要

铜绿假单胞菌中某些毒力相关基因的转录后调控是由一种小RNA结合蛋白RsmA实现的。在与气道上皮细胞相互作用的过程中，RsmA通过正向调控与毒力相关的III型分泌系统，促进了肌动蛋白解聚、细胞毒性以及铜绿假单胞菌的抗内化作用。

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本文引用的文献

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Influence of the regulatory protein RsmA on cellular functions in Pseudomonas aeruginosa PAO1, as revealed by transcriptome analysis.转录组分析揭示调控蛋白RsmA对铜绿假单胞菌PAO1细胞功能的影响。
Microbiology (Reading). 2006 Feb;152(Pt 2):405-418. doi: 10.1099/mic.0.28324-0.
2
Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.ExoY对肌动蛋白细胞骨架的破坏及其对铜绿假单胞菌侵袭的影响。
FEMS Microbiol Lett. 2005 Sep 1;250(1):71-6. doi: 10.1016/j.femsle.2005.06.044.
3
Mutation of retS, encoding a putative hybrid two-component regulatory protein in Pseudomonas aeruginosa, attenuates multiple virulence mechanisms.铜绿假单胞菌中编码假定的杂合双组分调节蛋白的retS发生突变，会减弱多种毒力机制。
Microbes Infect. 2005 Oct;7(13):1305-16. doi: 10.1016/j.micinf.2005.04.017. Epub 2005 Jun 13.
4
Quorum sensing negatively controls type III secretion regulon expression in Pseudomonas aeruginosa PAO1.群体感应负向调控铜绿假单胞菌PAO1中III型分泌调节子的表达。
J Bacteriol. 2005 Jun;187(11):3898-902. doi: 10.1128/JB.187.11.3898-3902.2005.
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Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.III型分泌外切酶S、T和Y在铜绿假单胞菌PAO1体内全身播散中的作用。
Infect Immun. 2005 Mar;73(3):1706-13. doi: 10.1128/IAI.73.3.1706-1713.2005.
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Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.多药外排泵MexCD - OprJ和MexEF - OprN的过表达与铜绿假单胞菌III型分泌的减少有关。
J Bacteriol. 2005 Feb;187(4):1384-91. doi: 10.1128/JB.187.4.1384-1391.2005.
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Characterisation of the regulatory RNA RsmB from Pseudomonas aeruginosa PAO1.铜绿假单胞菌PAO1中调控RNA RsmB的特性分析。
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