Thabet Farah, Sghiri Rim, Tabarki Brahim, Ghedira Ibtissem, Yacoub Moncef, Essoussi Ahmed Sahloul
Department of Pediatrics, Hospital Farhat Hached, Sousse, Tunisia.
Eur J Pediatr. 2006 Jul;165(7):435-6. doi: 10.1007/s00431-005-0053-4. Epub 2006 Apr 19.
Benzylthiouracil has been recently observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. We report an 8-year-old girl treated with benzylthiouracil for Graves's disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage. She responded to corticosteroids and discontinuation of benzylthiouracil. This represents the first pediatric case of benzylthiouracil-induced diffuse alveolar hemorrhage.