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ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil.

作者信息

Thabet Farah, Sghiri Rim, Tabarki Brahim, Ghedira Ibtissem, Yacoub Moncef, Essoussi Ahmed Sahloul

机构信息

Department of Pediatrics, Hospital Farhat Hached, Sousse, Tunisia.

出版信息

Eur J Pediatr. 2006 Jul;165(7):435-6. doi: 10.1007/s00431-005-0053-4. Epub 2006 Apr 19.

Abstract

Benzylthiouracil has been recently observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. We report an 8-year-old girl treated with benzylthiouracil for Graves's disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage. She responded to corticosteroids and discontinuation of benzylthiouracil. This represents the first pediatric case of benzylthiouracil-induced diffuse alveolar hemorrhage.

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