Agrawal Arpana, Edenberg Howard J, Foroud Tatiana, Bierut Laura J, Dunne Gerald, Hinrichs Anthony L, Nurnberger John I, Crowe Raymond, Kuperman Samuel, Schuckit Marc A, Begleiter Henri, Porjesz Bernice, Dick Danielle M
Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Behav Genet. 2006 Sep;36(5):640-50. doi: 10.1007/s10519-006-9069-4.
Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.
双胞胎研究结果表明，重叠的遗传因素会影响酒精依赖和非法药物依赖。利用酒精中毒遗传学合作研究（COGA）的数据，我们分别研究了4号染色体上GABAA受体基因簇中的69个单核苷酸多态性（SNP）与大麻及非法药物依赖之间的关联，以及它们作为与酒精依赖共现的表型之间的关联。结果表明，GABRA2基因中的SNP与大麻依赖和非法药物依赖之间存在关联。有趣的是，之前观察到的与酒精依赖相关的证据仅来自患有共病非法药物依赖的个体。4号染色体上GABAA基因簇中的其他基因与非法药物依赖无关联。
