基于二苯基茚满的蛋白质模拟物重现了α-螺旋上第i、i + 3、i + 4和i + 7位残基的投影。
Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix.
作者信息
Kim In Chul, Hamilton Andrew D
机构信息
Department of Chemistry, Yale University, P.O. Box 20810, New Haven, Connecticut 06511, USA.
出版信息
Org Lett. 2006 Apr 27;8(9):1751-4. doi: 10.1021/ol052956q.
PMID:16623542
Abstract
[structure: see text] The design of a nonpeptidic scaffold based on 4,7-diphenyl-1,6-disubstituted indanes mimicking i, i+3, i+4, and i+7 residues of an alpha-helix has been described, and its synthesis has been accomplished. This strategy makes general approaches possible to helix mimetic scaffolds that could be targeted to different proteins by changing the nature of the substituents.
摘要
[结构：见正文] 已描述了一种基于4,7-二苯基-1,6-二取代茚满的非肽支架的设计，该支架模拟α-螺旋的i、i + 3、i + 4和i + 7残基，并且已完成其合成。这种策略使得通过改变取代基的性质来靶向不同蛋白质的螺旋模拟支架的通用方法成为可能。
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