Fiddy Simon, Cattermole David, Xie Dong, Duan Xiao Yuan, Mott Richard
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
BMC Bioinformatics. 2006 Apr 19;7:210. doi: 10.1186/1471-2105-7-210.
Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use.
We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward.
IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.
大规模基因图谱绘制项目需要能够处理复杂表型、检测并纠正高通量基因分型错误且易于使用的数据管理系统。
我们开发了一种综合基因分型系统（IGS）来满足这一需求。IGS可安全地存储、编辑和分析基因分型和表型数据。它存储有关DNA样本、平板、引物、标记以及基因分型实验室生成的基因型的信息。数据结构合理，使得病例对照数据和家系数据的统计遗传分析都很简单直接。
IGS能够对复杂表型进行建模，并包含全基因组关联研究的基因型。该数据库使基因分析与数据管理整合成为可能。IGS网站http://bioinformatics.well.ox.ac.uk/project-igs.shtml包含更多信息。
