Elovainio Marko, Keltikangas-Järvinen Liisa, Pulkki-Råback Laura, Kivimäki Mika, Puttonen Sampsa, Viikari Liisa, Räsänen Leena, Mansikkaniemi Kristiina, Viikari Jorma, Raitakari Olli T
Department of Psychology, University of Helsinki, Finland.
Psychol Med. 2006 Jun;36(6):797-805. doi: 10.1017/S0033291706007574. Epub 2006 Apr 20.
We tested the hypothesis that depressive symptoms in healthy young adults would be associated with elevated levels of C-reactive proteins (CRP).
We studied the association between depressive symptoms and CRP in 1201 young adults, as a part of the on-going population-based Cardiovascular Risk in Young Finns Study. Depressive symptoms were determined by responses to a revised version of Beck's Depression Inventory in 1992 and 2001. CRP and other known cardiac risk factors were measured in 2001.
Higher depressive symptomatology in 1992 and in 2001 and their means score were related to higher CRP levels (B's range from 0.24 to 0.21, p < 0.001). These relationships persisted after separate adjustments for various risk factors including sex, age, education, oral contraceptive use, dietary fat, physical activity, alcohol consumption, smoking status, LDL-cholesterol, HDL-cholesterol, systolic blood pressure and history of acute infectious disease. Adjustments for obesity and triglycerides levels, however, somewhat attenuated the relationship between depressive symptoms and CRP.
We concluded that higher levels of depressive symptoms are associated with higher levels of CRP, but this association may largely be attributable to obesity or triglycerides.
我们检验了这样一个假设，即健康年轻成年人的抑郁症状与C反应蛋白（CRP）水平升高有关。
作为正在进行的基于人群的年轻芬兰人心血管风险研究的一部分，我们研究了1201名年轻成年人中抑郁症状与CRP之间的关联。抑郁症状通过对1992年和2001年修订版贝克抑郁量表的回答来确定。2001年测量了CRP和其他已知的心脏危险因素。
1992年和2001年较高的抑郁症状及其平均得分与较高的CRP水平相关（B值范围为0.24至0.21，p<0.001）。在对包括性别、年龄、教育程度、口服避孕药使用、饮食脂肪、体育活动、饮酒、吸烟状况、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、收缩压和急性传染病史等各种危险因素进行单独调整后，这些关系依然存在。然而，对肥胖和甘油三酯水平进行调整后，抑郁症状与CRP之间的关系有所减弱。
我们得出结论，较高水平的抑郁症状与较高水平的CRP相关，但这种关联可能很大程度上归因于肥胖或甘油三酯。
