McGill K, Cowley D, Moran L, Scates P, O'Leary A, Madden R H, Carroll C, McNamara E, Moore J E, Fanning S, Collins J D, Whyte P
Veterinary Public Health and Food Safety Research Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland.
Epidemiol Infect. 2006 Dec;134(6):1282-91. doi: 10.1017/S0950268806006200. Epub 2006 Apr 20.
The antimicrobial resistance profiles of Campylobacter isolates recovered from a range of retail food samples (n=374) and humans (n=314) to eight antimicrobial compounds were investigated. High levels of resistance in food C. jejuni isolates were observed for ceftiofur (58%), ampicillin (25%) and nalidixic acid (17%) with lower levels observed for streptomycin (7.9%) and chloramphenicol (8.3%). A total of 80% of human C. jejuni isolates were resistant to ceftiofur, while 17% showed resistance to ampicillin and nalidixic acid, 8.6% to streptomycin and 4.1% to chloramphenicol. Resistance to clinically relevant antimicrobials such as erythromycin, ciprofloxacin and tetracycline was 6.7, 12, and 15% respectively for all food isolates and was similar to corresponding resistance prevalences observed for human isolates, where 6.4, 12 and 13% respectively were found to be resistant. Comparisons of C. jejuni isolates in each location showed a high degree of similarity although some regional variations did exist. Comparison of total C. jejuni and C. coli populations showed minor differences, with C. jejuni isolates more resistant to ampicillin and ceftiofur. Multidrug resistance patterns showed some profiles common to human and clinical isolates.
对从一系列零售食品样本（n = 374）和人类样本（n = 314）中分离出的弯曲杆菌菌株针对八种抗菌化合物的耐药性进行了研究。食品空肠弯曲菌分离株中，头孢噻呋耐药率较高（58%），氨苄西林耐药率为25%，萘啶酸耐药率为17%，而链霉素耐药率较低（7.9%），氯霉素耐药率为8.3%。总共80%的人类空肠弯曲菌分离株对头孢噻呋耐药，而17%对氨苄西林和萘啶酸耐药，8.6%对链霉素耐药，4.1%对氯霉素耐药。所有食品分离株对红霉素、环丙沙星和四环素等临床相关抗菌药物的耐药率分别为6.7%、12%和15%，与人类分离株观察到的相应耐药率相似，人类分离株中分别有6.4%、12%和13%耐药。每个地点的空肠弯曲菌分离株比较显示出高度相似性，尽管确实存在一些区域差异。空肠弯曲菌和结肠弯曲菌总菌数的比较显示出微小差异，空肠弯曲菌分离株对氨苄西林和头孢噻呋的耐药性更强。多重耐药模式显示出一些人类和临床分离株共有的特征。
