Ferreira P G, Costa-e-Silva A, Aguas A P
Department of Anatomy, ICBAS (Abel Salazar Institute for Biomedical Sciences) and UMIB (Unit for Multidisciplinary for Biomedical Research), University of Porto, Largo Professor Abel Salazar, 2, Porto 4099-003, Portugal.
Res Vet Sci. 2006 Dec;81(3):362-5. doi: 10.1016/j.rvsc.2006.02.001. Epub 2006 Apr 18.
Calicivirus infection causes rabbit haemorrhagic disease (RHD) that kills more than 90% of adult animals, whereas young rabbits are naturally resistant to this viral disease. It has been proposed that the different response of adult and young rabbits to calicivirus infection is due to absence of viral receptors in respiratory and digestive systems of young animals. We have searched for liver disease in 4-week-old rabbits inoculated with a calicivirus suspension by intranasal and oral routes. These young rabbits showed cell damage and mononuclear infiltration of the liver. The hepatic lesions were associated with mild to moderate increase in circulating transaminases. We conclude that the previously reported reduction of viral receptors in the epithelium of respiratory and digestive systems of young rabbits does not inhibit calicivirus from inducing liver disease in these hosts.
杯状病毒感染会引发兔出血性疾病（RHD），导致超过90%的成年动物死亡，而幼兔对这种病毒性疾病具有天然抵抗力。有人提出，成年兔和幼兔对杯状病毒感染的不同反应是由于幼兔的呼吸道和消化系统中缺乏病毒受体。我们通过鼻内和口服途径给4周龄的兔子接种杯状病毒悬液，以寻找肝脏疾病。这些幼兔出现了肝脏细胞损伤和单核细胞浸润。肝脏病变与循环转氨酶轻度至中度升高有关。我们得出结论，先前报道的幼兔呼吸道和消化系统上皮中病毒受体的减少并不妨碍杯状病毒在这些宿主中诱发肝脏疾病。
