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[大鼠个体行为特征与脑能量代谢指标之间的相互关系]

[The interrelation between individual behavioral characteristics and the indices of brain energy metabolism in rats].

作者信息

Sarkisov K Iu, Nozdracheva L V, Kulikov M A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Sep-Oct;41(5):963-72.

PMID:1662447
Abstract

In rats with active type of behaviour in "open field" and "forced swimming" tests in response to weak stress (handling) both the rate of local blood flow (RLBF) and free oxygen tension level (pO2) in the brain are increased, and in rats with passive type of behaviour RLBF is increased, but the pO2 level is decreased. The character of pO2 level changes in the brain under stress is significantly (r = -0.74, p less than 0.001) connected with the level of depressiveness (time of passive swimming) and is nonsignificantly connected with the level of the motor activity. Indices of the active type of behaviour (the number of crossed squares, rearings, comings out to the center of the field and the time of extinction of the motor activity) positively correlate with succinate dehydrogenase (SDG) activity and negatively with NADH-dehydrogenase (NADH-DG) activity and the index of the passive type of behaviour (time of passive swimming) positively correlates with NADH-DG activity and negatively--with SDG activity.

摘要

在“旷场”和“强迫游泳”试验中表现出主动行为类型的大鼠,在受到轻微应激(处理)时,脑局部血流速率(RLBF)和游离氧张力水平(pO2)均升高;而表现出被动行为类型的大鼠,RLBF升高,但pO2水平降低。应激状态下脑内pO2水平变化的特征与抑郁程度(被动游泳时间)显著相关(r = -0.74,p < 0.001),与运动活动水平的相关性不显著。主动行为类型的指标(穿过的方格数、直立次数、进入场地中心的次数以及运动活动消失的时间)与琥珀酸脱氢酶(SDG)活性呈正相关,与NADH脱氢酶(NADH-DG)活性呈负相关;被动行为类型的指标(被动游泳时间)与NADH-DG活性呈正相关,与SDG活性呈负相关。

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