Rassovsky Yuri, Satz Paul, Alfano Mark S, Light Roger K, Zaucha Kenneth, McArthur David L, Hovda David
Neuropsychology Division, Neuropsychiatric Institute and Hospital, UCLA, Los Angeles, CA 90024, USA.
J Clin Exp Neuropsychol. 2006 May;28(4):581-91. doi: 10.1080/13803390500434474.
Following traumatic brain injury (TBI), patients often report memory difficulties, as well as reduced information processing speed. However, it remains unclear the extent to which these deficits contribute to functional impairment. In the present study, we compared the relative contribution of verbal memory and information processing speed to functional impairment at 12-month post-injury, in 87 patients with moderate-to-severe TBI. Employing structural equation modeling, we found that information processing speed, but not verbal memory functions, significantly mediated the relationship between TBI severity and post-TBI adaptive functioning. These findings suggest that despite the pervasive memory complaints among patients with TBI, it is the impact of neurotrauma on frontal systems that appears to be primarily responsible for patients' difficulties in social and occupational functioning.
创伤性脑损伤（TBI）后，患者常报告有记忆困难以及信息处理速度下降的情况。然而，这些缺陷在多大程度上导致功能障碍仍不清楚。在本研究中，我们比较了87例中重度TBI患者受伤后12个月时言语记忆和信息处理速度对功能障碍的相对影响。采用结构方程模型，我们发现信息处理速度而非言语记忆功能显著介导了TBI严重程度与TBI后适应性功能之间的关系。这些发现表明，尽管TBI患者普遍存在记忆方面的主诉，但神经创伤对额叶系统的影响似乎是导致患者社交和职业功能出现困难的主要原因。
