Raabe N K, Storstein L
Department of Clinical Oncology and Radiotherapy, Ullevaal Sykehus, Oslo, Norway.
Acta Oncol. 1991;30(7):843-6. doi: 10.3109/02841869109091832.
Cardiac arrhythmias have been reported during doxorubicin infusion. The aim of the present study was to investigate the prevalence of arrhythmias and elucidate whether previous cardiac disease might increase the probability of treatment-related ectopic activity. In 18 patients with small cell lung cancer, 11 with concomitant heart disease, electrocardiogram (ECG) was continuously registered by a portable tape recorder 24 h before, during and 24 h after doxorubicin infusion (Holter monitoring). The only significant finding was an increased number of bigeminal ventricular extrasystoles after doxorubicin infusion. A trend of increased number of ventricular extrasystoles was also observed. The study suggests that pretreatment arrhythmias do not dispose for increased cardiac irritability and that bolus injections of doxorubicin do not seriously influence the ectopic activity in patients with and without heart disease.
据报道，在阿霉素输注期间会出现心律失常。本研究的目的是调查心律失常的患病率，并阐明既往心脏病是否可能增加治疗相关异位活动的可能性。对18例小细胞肺癌患者（其中11例伴有心脏病），在阿霉素输注前24小时、输注期间及输注后24小时，通过便携式磁带记录仪连续记录心电图（动态心电图监测）。唯一显著的发现是阿霉素输注后二联律室性期前收缩数量增加。还观察到室性期前收缩数量增加的趋势。该研究表明，预处理时的心律失常不会导致心脏易激性增加，推注阿霉素对有或无心脏病患者的异位活动均无严重影响。
