Lander Elliot B, Berman Mark H, See Jackie R
California Stem Cell Treatment Center, Rancho Mirage, Calif.
Plast Reconstr Surg Glob Open. 2016 Mar 2;4(3):e631. doi: 10.1097/GOX.0000000000000622. eCollection 2016 Mar.
This pilot study was used to evaluate safety and subjective outcomes in a small series of Peyronie's disease patients using a combination of autologous stromal vascular fraction (SVF) and penile shock wave treatments. SVF can be procured and deployed into Peyronie's plaques, enabling the surgeons to procure and mobilize significant numbers of both adult mesenchymal stem cells and antiinflammatory cytokines released from the adipose collagen matrix after collagen digestion. Penile shock wave therapy stimulates targeted tissues and may activate stem cells found in the SVF and promote healing and fibrosis mitigation.
SVF isolated from lipoaspirate was deployed by injection into 11 patients with Peyronie's plaques in combination with a series of shock wave treatments. Subjective outcomes tests performed at baseline and at 6 months included the Erectile Hardness Grading Score and the Peyronie's Disease Questionnaire (Questions 1-6).
All patients noted subjective improvement in curvature and subjective reduction in plaque size. Seven patients reported improvement in erectile function. Mean Erectile Hardness Grading Score increased from 2.7 to 3.5, and mean Peyronie's Disease Questionnaire scores decreased from 15.0 to 8.7.
SVF is known to have scar mitigation, antiinflammatory, immunomodulatory, and regenerative effects, and it has been used for a variety of conditions on an investigational basis. SVF containing mesenchymal stem cells can be procured in a closed surgical system from lipoaspirate in a same-day setting and deployed directly into Peyronie's plaques in combination with penile shock wave therapy resulting in plaque mitigation.
本初步研究旨在评估一小部分佩罗尼氏病患者采用自体基质血管成分（SVF）与阴茎冲击波治疗相结合的方法后的安全性和主观疗效。SVF可以获取并注入佩罗尼氏斑块，使外科医生能够获取并动员大量成年间充质干细胞以及胶原消化后从脂肪胶原基质中释放的抗炎细胞因子。阴茎冲击波疗法刺激目标组织，可能激活SVF中发现的干细胞并促进愈合和减轻纤维化。
从抽脂物中分离出的SVF通过注射注入11例患有佩罗尼氏斑块的患者体内，并结合一系列冲击波治疗。在基线和6个月时进行的主观疗效测试包括勃起硬度分级评分和佩罗尼氏病问卷（问题1 - 6）。
所有患者均指出在弯曲度方面有主观改善，斑块大小有主观减小。7例患者报告勃起功能有所改善。平均勃起硬度分级评分从2.7提高到3.5，平均佩罗尼氏病问卷评分从15.0降至8.7。
已知SVF具有减轻瘢痕、抗炎、免疫调节和再生作用，并且已在研究基础上用于多种病症。含有间充质干细胞的SVF可以在封闭手术系统中于同一天从抽脂物中获取，并与阴茎冲击波疗法相结合直接注入佩罗尼氏斑块，从而减轻斑块。
