2,2 - 二甲基 - 1,3 - 苯并二恶烷 - 4 - 酮官能团的高效且选择性还原方案，可轻松提供取代水杨醛和2 - 羟基苄醇。
Efficient and selective reduction protocols of the 2,2-dimethyl-1,3-benzodioxan-4-one functional group to readily provide both substituted salicylaldehydes and 2-hydroxybenzyl alcohols.
作者信息
Bajwa Naval, Jennings Michael P
机构信息
Department of Chemistry, University of Alabama, 500 Campus Drive, Tuscaloosa, Alabama 35487-0336, USA.
出版信息
J Org Chem. 2006 Apr 28;71(9):3646-9. doi: 10.1021/jo0601664.
PMID:16626159
Abstract
Two complementary procedures have been developed that selectively allow for the synthesis of either substituted salicylaldehydes or the corresponding 2-hydroxylbenzyl alcohols upon treatment of the 2,2-dimethyl-1,3-benzodioxan-4-one functional group with DIBAL-H or LAH, respectively.
摘要
已经开发出两种互补的方法，分别用二异丁基氢化铝（DIBAL-H）或氢化铝锂（LAH）处理2,2-二甲基-1,3-苯并二恶烷-4-酮官能团时，能够选择性地合成取代水杨醛或相应的2-羟基苄醇。
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