Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas del IPN, Prol. de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Deleg. Gustavo A. Madero, México, DF 11340, Mexico.
Molecules. 2012 Nov 22;17(12):13864-78. doi: 10.3390/molecules171213864.
The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
Weinreb 酰胺 2a,b 可由 α,α-二甲氧基乙酸 1c,d 制得。2 上的一系列代表性亲核加成反应（RMgX 和 RLi）得到 α-酮缩醛 3a-j，产率为 70-99%。这些化合物代表了具有重要合成价值的多功能官能团的排列方式，如（±）-沙丁胺醇的合成所示。
