Li Wan, Daems Els, Van de Woestijne Karel P, Van Diest Ilse, Gallego Jorge, De Peuter Steven, Bogaerts Katleen, Van den Bergh Omer
Department of Psychology, University of Leuven, Tiensestraat 102, B-3000 Leuven, Belgium.
Physiol Behav. 2006 Jun 15;88(1-2):47-54. doi: 10.1016/j.physbeh.2006.03.001. Epub 2006 Apr 19.
We investigated the effects of anxiety on the intensity of air hunger during gradually increasing levels of CO2 until the end-tidal fractional concentration of CO2 was 7.9% or air hunger was intolerable. Normal high and low (trait) anxious participants (N=23) went through three rebreathing trials (15 min interval). Breathing behaviour was continuously monitored and air hunger was rated every 12 s. The threshold for responding to the increased CO2 was always lower for the subjective rating than for the ventilatory response. Habituation across trials was observed for both the ventilatory response and the air hunger rating regardless of anxiety. However, beyond the threshold, the slope in air hunger ratings decreased across trials in low anxious persons and tended to increase in high anxious persons (interaction P<0.05). No differences occurred in the slopes of the breathing responses. The findings documented uncoupling of the physiological and subjective responses during CO2-induced air hunger.
我们研究了焦虑对在逐渐增加二氧化碳水平直至呼气末二氧化碳分数浓度达到7.9%或呼吸急促无法忍受时的呼吸急促强度的影响。正常的高焦虑和低焦虑（特质）参与者（N = 23）进行了三次重复呼吸试验（间隔15分钟）。持续监测呼吸行为，并每12秒对呼吸急促进行评分。对于主观评分而言，对增加的二氧化碳做出反应的阈值总是低于通气反应的阈值。无论焦虑程度如何，在重复呼吸试验中，通气反应和呼吸急促评分均观察到适应性变化。然而，超过阈值后，低焦虑者的呼吸急促评分斜率在重复试验中下降，而高焦虑者的斜率则趋于增加（交互作用P<0.05）。呼吸反应的斜率没有差异。这些发现证明了在二氧化碳诱发的呼吸急促过程中生理反应和主观反应的解耦。
