Department of Physiological Sciences, University of Florida, Gainesville, Florida, USA.
Psychophysiology. 2011 Jun;48(6):808-12. doi: 10.1111/j.1469-8986.2010.01141.x. Epub 2010 Oct 29.
Reduced perception of respiratory sensations is associated with negative treatment outcome in asthma. We examined whether habituation in the neural processing of repeatedly experienced respiratory sensations may underlie subjective reports of reduced respiratory perception. Respiratory-related evoked potentials (RREP) elicited by inspiratory occlusions and reports of respiratory perception were compared between early and late experimental periods in healthy subjects. Reports of respiratory perception were reduced during late, compared to early, experimental periods. This was paralleled by reduced magnitudes in RREP components N1, P2, and P3 in late, compared to early, experimental periods. Habituation in the neural processing of respiratory sensations is a potential mechanism that underlies subjective reports of reduced respiratory perception and might represent a risk factor for reduced perception of respiratory sensations in asthma.
呼吸感觉的减弱与哮喘的负面治疗结果有关。我们研究了反复经历的呼吸感觉的神经处理习惯化是否是主观呼吸感觉减弱的基础。我们比较了健康受试者早期和晚期实验期间呼吸相关诱发电位（RREP）和呼吸感觉报告。与早期相比，晚期的呼吸感觉报告减少。这与晚期与早期相比，RREP 成分 N1、P2 和 P3 的幅度减小相平行。呼吸感觉神经处理的习惯化是主观报告呼吸感觉减弱的潜在机制，可能代表哮喘中呼吸感觉减弱的危险因素。
