1993年克罗尼安讲座。内皮：血液循环的指挥者。
The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation.
作者信息
Vane J R
机构信息
William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, U.K.
出版信息
Philos Trans R Soc Lond B Biol Sci. 1994 Jan 29;343(1304):225-46. doi: 10.1098/rstb.1994.0023.
The vascular endothelium plays a vital role in the control of the circulation. It metabolizes various vasoactive substances, coverts angiotensin I to angiotensin II and secretes the potent vasodilators prostacyclin and EDRF (NO) and the vasoconstrictor peptide endothelin-1. The balance between these mediators determines the responses of the cardiovascular system in diseases such as hypertension, atherosclerosis and myocardial infarction.
血管内皮在循环控制中起着至关重要的作用。它代谢多种血管活性物质，将血管紧张素I转化为血管紧张素II，并分泌强效血管舒张剂前列环素和内皮舒张因子（一氧化氮）以及血管收缩肽内皮素-1。这些介质之间的平衡决定了心血管系统在诸如高血压、动脉粥样硬化和心肌梗死等疾病中的反应。
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