Navarro Lionel, Dunoyer Patrice, Jay Florence, Arnold Benedict, Dharmasiri Nihal, Estelle Mark, Voinnet Olivier, Jones Jonathan D G
Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
Science. 2006 Apr 21;312(5772):436-9. doi: 10.1126/science.1126088.
Plants and animals activate defenses after perceiving pathogen-associated molecular patterns (PAMPs) such as bacterial flagellin. In Arabidopsis, perception of flagellin increases resistance to the bacterium Pseudomonas syringae, although the molecular mechanisms involved remain elusive. Here, we show that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3. Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance.
植物和动物在感知到病原体相关分子模式（PAMP）（如细菌鞭毛蛋白）后会激活防御机制。在拟南芥中，鞭毛蛋白的感知增强了对丁香假单胞菌的抗性，尽管其中涉及的分子机制仍不清楚。在这里，我们表明一种源自鞭毛蛋白的肽会诱导一种植物微小RNA（miRNA），该miRNA会负向调节F-box生长素受体TIR1、AFB2和AFB3的信使RNA。生长素信号传导的抑制会限制丁香假单胞菌的生长，这表明生长素与疾病易感性有关，而miRNA介导的生长素信号传导抑制与抗性有关。
