Sespendole是一种由土生假葡萄孢菌FKA - 25产生的巨噬细胞中脂滴合成的新型抑制剂。
Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25.
作者信息
Uchida Ryuji, Kim Yong-Pil, Namatame Ichiji, Tomoda Hiroshi, Omura Satoshi
机构信息
School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
出版信息
J Antibiot (Tokyo). 2006 Feb;59(2):93-7. doi: 10.1038/ja.2006.13.
PMID:16629409
Abstract
Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 microM, respectively.
摘要
瑟斯喷多是从真菌菌株土生假葡萄孢菌FKA - 25的培养液中分离得到的一种巨噬细胞中脂滴形成的抑制剂。该化合物抑制小鼠巨噬细胞中胆固醇酯和三酰甘油的合成，IC50值分别为4.0和3.2微摩尔。
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