P300波幅作为青少年男性外化行为的一个指标。
P300 amplitude as an indicator of externalizing in adolescent males.
作者信息
Patrick Christopher J, Bernat Edward M, Malone Stephen M, Iacono William G, Krueger Robert F, McGue Matt
机构信息
Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Psychophysiology. 2006 Jan;43(1):84-92. doi: 10.1111/j.1469-8986.2006.00376.x.
Abstract
Reduced P300 amplitude is reliably found in individuals with a personal or family history of alcohol problems. However, alcoholism is part of a broader externalizing spectrum that includes other substance use and antisocial disorders. We hypothesized that reduced P300 is an indicator of the common factor that underlies disorders within this spectrum. Community males (N=969) were assessed at age 17 in a visual oddball task. Externalizing was defined as the common factor underlying symptoms of alcohol dependence, drug dependence, nicotine dependence, conduct disorder, and adult antisocial behavior. A robust association was found between reduced P300 amplitude and the externalizing factor, and this relation accounted for links between specific externalizing disorders and P300. Our findings indicate that reduced P300 amplitude is an indicator of the broad neurobiological vulnerability that underlies disorders within the externalizing spectrum.
摘要
在有个人或家族酒精问题史的个体中，可靠地发现P300波幅降低。然而，酒精中毒是更广泛的外化谱系的一部分，该谱系包括其他物质使用和反社会障碍。我们假设P300降低是该谱系内各种障碍背后共同因素的一个指标。对969名社区男性在17岁时进行了视觉Oddball任务评估。外化被定义为酒精依赖、药物依赖、尼古丁依赖、品行障碍和成人反社会行为症状背后的共同因素。发现P300波幅降低与外化因素之间存在强烈关联，并且这种关系解释了特定外化障碍与P300之间的联系。我们的研究结果表明，P300波幅降低是外化谱系内各种障碍背后广泛神经生物学易感性的一个指标。
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