变形：DEAD盒解旋酶Vasa解开RNA双链
Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa.
作者信息
Linder Patrick, Lasko Paul
机构信息
Department of Microbiology and Molecular Medicine, Centre Médical Universitaire, University of Geneva, CH-1211 Genève 4, Switzerland.
出版信息
Cell. 2006 Apr 21;125(2):219-21. doi: 10.1016/j.cell.2006.03.030.
PMID:16630807
Abstract
RNA helicases of the DEAD-box family are involved in essentially all RNA-dependent cellular processes. In this issue of Cell, Sengoku et al. (2006) solve the structure of the DEAD-box protein Vasa in the presence of RNA and a nonhydrolyzable ATP analog and provide important insights into how this family of helicases unwinds RNA.
摘要
DEAD-box家族的RNA解旋酶基本上参与了所有依赖RNA的细胞过程。在本期《细胞》杂志中，Sengoku等人（2006年）解析了在存在RNA和一种不可水解的ATP类似物的情况下DEAD-box蛋白Vasa的结构，并为该解旋酶家族如何解开RNA提供了重要见解。
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