麻痹感官：TRPA1在机械感觉和冷觉中的作用

Numbing the senses: role of TRPA1 in mechanical and cold sensation.

作者信息

Story Gina M, Gereau Robert W

机构信息

Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

出版信息

Neuron. 2006 Apr 20;50(2):177-80. doi: 10.1016/j.neuron.2006.04.009.

DOI:10.1016/j.neuron.2006.04.009

PMID:16630827

Abstract

In this issue of Neuron, Kwan et al. demonstrate that TRPA1 is critical for the transduction of noxious cold and mechanical stimuli, as well as in mediating the activation of nociceptors by endogenous and natural irritants. Differences between the present report and a previous study indicate that further study is needed to reach a consensus on the role of TRPA1 in the transduction of mechanical and noxious cold stimuli.

摘要

在本期《神经元》杂志中，关等人证明了瞬时受体电位锚蛋白1（TRPA1）对于有害冷刺激和机械刺激的转导至关重要，并且在介导内源性和天然刺激物激活伤害感受器方面也发挥着作用。本报告与先前一项研究之间的差异表明，需要进一步研究才能就TRPA1在机械和有害冷刺激转导中的作用达成共识。