喂食含t10，c12-共轭亚油酸和c9，t11-共轭亚油酸日粮的小鼠肝脏、脂肪组织、脾脏和心脏的脂肪酸组成
Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid.
作者信息
Kelley Darshan S, Bartolini Giovanni L, Newman John W, Vemuri Madhuri, Mackey Bruce E
机构信息
Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2006 May;74(5):331-8. doi: 10.1016/j.plefa.2006.02.008. Epub 2006 May 2.
Conjugated linoleic acid (CLA) isomers have unique effects on tissue lipids. Here we investigated the influence of individual CLA isomers on the lipid weight and fatty acid composition of lipid metabolizing (i.e. liver and retroperitoneal adipose) and lipid sensitive (i.e. spleen and heart) tissues. Female mice (8 week old; n=6/group) were fed either a control or one of the two CLA isomer supplemented (0.5%) diets for 8 weeks. The cis-9, trans-11-CLA diet reduced the 18:1n-9 wt% by 20-50% in liver, adipose tissue, and spleen, reduced the spleen n-3 polyunsaturated fatty acid (PUFA) by 90%, and increased the n-6 PUFA wt% by 20-50% in all tissues except heart. The trans-10, cis-12-CLA reduced both the n-6 and n-3 PUFA wt% in liver (>50%), reduced the heart n-3 PUFA wt% by 25%, and increased the wt% of spleen n-3 PUFA by 700%. The functional consequences of such changes in tissue fatty acid composition need to be investigated.
共轭亚油酸（CLA）异构体对组织脂质具有独特作用。在此，我们研究了单个CLA异构体对脂质代谢组织（即肝脏和腹膜后脂肪）以及脂质敏感组织（即脾脏和心脏）的脂质重量和脂肪酸组成的影响。将雌性小鼠（8周龄；每组n = 6）喂食对照饮食或两种CLA异构体补充饮食（0.5%）之一，持续8周。顺式-9，反式-11-CLA饮食使肝脏、脂肪组织和脾脏中的18:1n-9重量百分比降低了20 - 50%，使脾脏中的n-3多不饱和脂肪酸（PUFA）降低了90%，并使除心脏外的所有组织中的n-6 PUFA重量百分比增加了20 - 50%。反式-10，顺式-12-CLA降低了肝脏中n-6和n-3 PUFA的重量百分比（>50%），使心脏中n-3 PUFA的重量百分比降低了25%，并使脾脏中n-3 PUFA的重量百分比增加了700%。组织脂肪酸组成的这种变化所产生的功能后果有待研究。
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