Madjid Mohammad, Willerson James T, Casscells S Ward
University of Texas-Houston Health Science Center, Houston, Texas, USA.
J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C80-5. doi: 10.1016/j.jacc.2005.11.050.
Up to two-thirds of acute myocardial infarctions develop at sites of culprit lesions without a significant stenosis. New imaging techniques are needed to identify those lesions with an increased risk of developing an acute complication in the near future. Inflammation is a hallmark feature of these vulnerable/high-risk plaques. We have shown that inflamed atherosclerotic plaques are hot and their surface temperature correlates with an increased number of macrophages and decreased fibrous-cap thickness. Multiple animal and human experiments have shown that temperature heterogeneity correlates with arterial inflammation in vivo. Several coronary temperature mapping catheters are currently being developed and studied. These thermography methods can be used in the future to detect vulnerable plaques, potentially to determine patients' prognosis, and to study the plaque-stabilizing effects of different medications.
高达三分之二的急性心肌梗死发生在无明显狭窄的罪犯病变部位。需要新的成像技术来识别那些在不久的将来发生急性并发症风险增加的病变。炎症是这些易损/高危斑块的一个标志性特征。我们已经表明，发炎的动脉粥样硬化斑块是热的，其表面温度与巨噬细胞数量增加和纤维帽厚度减小相关。多项动物和人体实验表明，温度异质性与体内动脉炎症相关。目前正在研发和研究几种冠状动脉温度测绘导管。这些热成像方法未来可用于检测易损斑块，有可能确定患者的预后，并研究不同药物的斑块稳定作用。
