Andrian E, Grenier D, Rouabhia M
Groupe de Recherche en Ecologie Buccale, Faculté de médecine dentaire, Université Laval, Quebec City, Canada.
J Dent Res. 2006 May;85(5):392-403. doi: 10.1177/154405910608500502.
Emerging data on the consequences of the interactions between invasive oral bacteria and host cells have provided new insights into the pathogenesis of periodontal disease. Indeed, modulation of the mucosal epithelial barrier by pathogenic bacteria appears to be a critical step in the initiation and progression of periodontal disease. Periodontopathogens such as Porphyromonas gingivalis have developed different strategies to perturb the structural and functional integrity of the gingival epithelium. P. gingivalis adheres to, invades, and replicates within human epithelial cells. Adhesion of P. gingivalis to host cells is multimodal and involves the interaction of bacterial cell-surface adhesins with receptors expressed on the surfaces of epithelial cells. Internalization of P. gingivalis within host cells is rapid and requires both bacterial contact-dependent components and host-induced signaling pathways. P. gingivalis also subverts host responses to bacterial challenges by inactivating immune cells and molecules and by activating host processes leading to tissue destruction. The adaptive ability of these pathogens that allows them to survive within host cells and degrade periodontal tissue constituents may contribute to the initiation and progression of periodontitis. In this paper, we review current knowledge on the molecular cross-talk between P. gingivalis and gingival epithelial cells in the development of periodontitis.
关于侵袭性口腔细菌与宿主细胞相互作用后果的新数据为牙周病的发病机制提供了新见解。事实上，病原菌对黏膜上皮屏障的调节似乎是牙周病发生和发展的关键步骤。牙龈卟啉单胞菌等牙周病原体已形成不同策略来扰乱牙龈上皮的结构和功能完整性。牙龈卟啉单胞菌可黏附、侵入并在人上皮细胞内复制。牙龈卟啉单胞菌与宿主细胞的黏附是多模式的，涉及细菌细胞表面黏附素与上皮细胞表面表达的受体之间的相互作用。牙龈卟啉单胞菌在宿主细胞内的内化迅速，需要细菌接触依赖成分和宿主诱导的信号通路。牙龈卟啉单胞菌还通过使免疫细胞和分子失活以及激活导致组织破坏的宿主过程来颠覆宿主对细菌挑战的反应。这些病原体在宿主细胞内存活并降解牙周组织成分的适应能力可能有助于牙周炎的发生和发展。在本文中，我们综述了关于牙龈卟啉单胞菌与牙龈上皮细胞在牙周炎发展过程中分子相互作用的现有知识。
