Ramachary Dhevalapally B, Kishor M, Reddy G Babul
School of Chemistry, University of Hyderabad, India.
Org Biomol Chem. 2006 May 7;4(9):1641-6. doi: 10.1039/b602696f. Epub 2006 Mar 23.
Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.
分别利用脯氨酸和脯氨酸/金属碳酸盐催化，开发了新颖、经济且环保的一锅三组分酮、碳氢键酸、二氢吡啶和卤代烷的克诺文纳盖尔/氢化（K/H）反应以及四组分克诺文纳盖尔/氢化/烷基化（K/H/A）反应。这些K/H和K/H/A反应的许多产物在药物化学中具有直接应用。
