Ramachary Dhevalapally B, Reddy G Babul
School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India.
Org Biomol Chem. 2006 Dec 21;4(24):4463-8. doi: 10.1039/b612611a. Epub 2006 Nov 6.
Economic and environmentally friendly bio-mimetic one-pot three and four-component Knoevenagel-hydrogenation (K-H), five-component Knoevenagel-hydrogenation-alkylation (K-H-A) and six-component Knoevenagel-hydrogenation-alkylation-Huisgen cycloaddition (K-H-A-HC) reactions of aldehydes, CH-acids, o-phenylenediamine, alkyl halides and azides using proline, proline-metal carbonate and proline-metal carbonate-Cu(I)-catalysis, respectively have been developed. Many of K-H and K-H-A compounds have direct application in pharmaceutical chemistry.
分别利用脯氨酸、脯氨酸 - 金属碳酸盐和脯氨酸 - 金属碳酸盐 - 铜（I）催化，开发了醛、碳氢酸、邻苯二胺、卤代烃和叠氮化物的经济且环境友好的仿生一锅法三组分和四组分克诺文纳格尔 - 氢化（K - H）、五组分克诺文纳格尔 - 氢化 - 烷基化（K - H - A）以及六组分克诺文纳格尔 - 氢化 - 烷基化 - 惠斯根环加成（K - H - A - HC）反应。许多K - H和K - H - A化合物在药物化学中有直接应用。
