Hebert D N, Carruthers A
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical Centre, Worcester 01605.
Curr Opin Cell Biol. 1991 Aug;3(4):702-9. doi: 10.1016/0955-0674(91)90044-y.
The past year has seen a flurry of activity in the area of protein-mediated hexose uniport. Topics of interest covered here include: structure-function studies; the interaction of glucose carriers with glycolytic enzymes; regulation of cell surface glucose-carrier concentrations by insulin and the signalling mechanisms involved; and the role of the glucose-carrier isoform, GLUT2, in pancreatic beta-cell glucose-dependent insulin secretion. Nucleoside uniport and Glu-Asp antiport are also discussed briefly.
过去一年里，蛋白质介导的己糖单向转运领域开展了一系列活动。这里涵盖的感兴趣的主题包括：结构-功能研究；葡萄糖载体与糖酵解酶的相互作用；胰岛素对细胞表面葡萄糖载体浓度的调节及相关信号传导机制；以及葡萄糖载体异构体GLUT2在胰腺β细胞葡萄糖依赖性胰岛素分泌中的作用。还简要讨论了核苷单向转运和Glu-Asp反向转运。
