Sakoda Yoritake, Arimori Yojiro, Ueno Masakatsu, Matsumoto Takafumi
Department of Respiratory Medicine, St. Mary's Hospital, Japan.
Intern Med. 2017;56(2):203-206. doi: 10.2169/internalmedicine.56.7363. Epub 2017 Jan 15.
A 39-year-old man treated with dasatinib for chronic myelogenous leukaemia presented to our hospital with haemoptysis, coughing, and dyspnoea. Chest radiography and computed tomography revealed ground-glass opacities and a crazy-paving pattern. Bronchoalveolar lavage was not performed due to serious hypoxemia and bleeding. Significant bleeding from the peripheral bronchi led to a diagnosis of an alveolar haemorrhage. Dasatinib-induced alveolar haemorrhaging was suspected based on the clinical findings. His condition improved immediately after dasatinib withdrawal and initiation of steroid therapy. Reports of alveolar haemorrhaging induced by dasatinib are rare. As such, this is considered an important case.
一名39岁的慢性髓性白血病男性患者，接受达沙替尼治疗，因咯血、咳嗽和呼吸困难前来我院就诊。胸部X线和计算机断层扫描显示磨玻璃影和铺路石样改变。由于严重低氧血症和出血，未进行支气管肺泡灌洗。外周支气管大量出血导致肺泡出血的诊断。根据临床表现怀疑为达沙替尼诱导的肺泡出血。停用达沙替尼并开始使用类固醇治疗后，他的病情立即好转。达沙替尼诱导肺泡出血的报道很少。因此，这被认为是一个重要病例。
