Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior 474011, India.
Environ Toxicol Pharmacol. 2013 Nov;36(3):779-86. doi: 10.1016/j.etap.2013.07.010. Epub 2013 Jul 23.
Hepatotoxicity is the most serious adverse effect related to tuberculosis treatment which interrupts the successful completion of tuberculosis treatment. The purpose of this study was to assess therapeutic effect of thymoquinone (TQ) against anti-tuberculosis drugs (ATD) induced liver damage. Rats were treated with ATD for 8 weeks (3 days/week) as given for the treatment of TB. This was followed by therapy of TQ for 8 weeks (3 days/week). Administration of combined ATD induced hepatotoxicity was evident from a significant elevation in the AST, ALT, ALP, bilirubin, albumin, cholesterol, urea, uric acid, creatinine, LPO and decreased activities of enzymes. These altered variables were significantly reversed toward control after treatment with TQ. Histological studies also supported biochemical findings. Results of this study strongly indicated protective effect of TQ and thus, can be expected as promising protective agent in maintenance of normal hepatic function during treatment with ATD.
肝毒性是与结核病治疗相关的最严重的不良反应，会中断结核病治疗的顺利完成。本研究旨在评估胸腺醌（TQ）对抗结核药物（ATD）诱导的肝损伤的治疗效果。大鼠接受 ATD 治疗 8 周（每周 3 天），这是结核病治疗的标准疗程。随后，TQ 治疗 8 周（每周 3 天）。联合 ATD 的给药导致明显的肝毒性，AST、ALT、ALP、胆红素、白蛋白、胆固醇、尿素、尿酸、肌酐、LPO 显著升高，而酶的活性降低。用 TQ 治疗后，这些改变的变量显著向对照恢复。组织学研究也支持生化发现。本研究结果强烈表明 TQ 具有保护作用，因此，有望成为 ATD 治疗期间维持正常肝功能的有前途的保护剂。
