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长期利血平化大鼠作为囊性纤维化的一种可能模型。I. 颌下腺的形态学和超微结构

The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.

作者信息

Martinez J R, Adelstein E, Quissel D, Barbero G J

出版信息

Pediatr Res. 1975 May;9(5):463-9. doi: 10.1203/00006450-197505000-00001.

DOI:10.1203/00006450-197505000-00001
PMID:166347
Abstract

Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis. The salivary exocrinopathy is characterized by increased amounts of PAS-reactive mucoprotein in the acinar cells and by obstruction and dilatation of ducts by precipitated material with the same staining characteristics as those found in the acinar elements.

摘要

用利血平治疗7天的大鼠，其颌下腺会出现结构变化，类似于囊性纤维化中所报道的变化。唾液腺外分泌病的特征是腺泡细胞中PAS反应性粘蛋白含量增加，以及导管被具有与腺泡成分相同染色特征的沉淀物质阻塞和扩张。

相似文献

1
The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.长期利血平化大鼠作为囊性纤维化的一种可能模型。I. 颌下腺的形态学和超微结构
Pediatr Res. 1975 May;9(5):463-9. doi: 10.1203/00006450-197505000-00001.
2
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.长期服用利血平的大鼠作为囊性纤维化的一种可能模型。II. 颌下唾液的比较及纤毛抑制作用。
Pediatr Res. 1975 May;9(5):470-5. doi: 10.1203/00006450-197505000-00002.
3
The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland.
Pediatr Res. 1977 Jul;11(7):827-32. doi: 10.1203/00006450-197707000-00010.
4
The reserpinized rat in the study of cystic fibrosis: x-ray microanalysis of submandibular gland and pancreas.利血平化大鼠在囊性纤维化研究中的应用：下颌下腺和胰腺的X射线微分析
Ultrastruct Pathol. 1982 Jul-Sep;3(3):285-93. doi: 10.3109/01913128209016654.
5
Histochemistry and ultrastructure of rat submandibular acinar cells: effects of chronic reserpine on secretion.大鼠下颌下腺腺泡细胞的组织化学与超微结构：利血平慢性给药对分泌的影响
Lab Invest. 1978 Aug;39(2):157-66.
6
X-ray microanalysis of exocrine glands in animal models for cystic fibrosis.囊性纤维化动物模型中外分泌腺的X射线微量分析。
Scan Electron Microsc. 1985(Pt 4):1583-601.
7
Tracheal potential difference in the reserpine and isoproterenol rat models of cystic fibrosis.利血平和异丙肾上腺素诱导的囊性纤维化大鼠模型中的气管电位差
Exp Lung Res. 1990 Nov-Dec;16(6):661-70. doi: 10.3109/01902149009087887.
8
Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol.利血平和异丙肾上腺素长期处理后大鼠下颌下腺中糖缀合物的变化。
Histochemistry. 1988;90(4):285-8. doi: 10.1007/BF00495972.
9
The chronically reserpinized rat as an animal model for cystic fibrosis: I. Acute effect of isoproterenol and pilocarpine upon pulmonary lavage fluid.长期服用利血平的大鼠作为囊性纤维化的动物模型：I. 异丙肾上腺素和毛果芸香碱对肺灌洗液的急性作用。
Pediatr Res. 1979 Jun;13(6):760-3. doi: 10.1203/00006450-197906000-00008.
10
The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland.在囊性纤维化研究中用异丙肾上腺素长期处理的大鼠：下颌下腺的X射线微分析
Exp Mol Pathol. 1984 Jun;40(3):391-400. doi: 10.1016/0014-4800(84)90056-x.

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Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom.来自巴西矛头蝮组织的与毒液相关的转录本为蛇毒的产生和进化提供了新的分子见解。
Mol Biol Evol. 2015 Mar;32(3):754-66. doi: 10.1093/molbev/msu337. Epub 2014 Dec 9.
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A rat mammary tumor model induced by the organophosphorous pesticides parathion and malathion, possibly through acetylcholinesterase inhibition.一种由有机磷农药对硫磷和马拉硫磷诱导的大鼠乳腺肿瘤模型，可能是通过抑制乙酰胆碱酯酶实现的。
Environ Health Perspect. 2001 May;109(5):471-9. doi: 10.1289/ehp.01109471.
3
Mucin biosynthesis and secretion in the respiratory tract.
呼吸道中的黏蛋白生物合成与分泌
Environ Health Perspect. 1984 Apr;55:193-204. doi: 10.1289/ehp.8455193.
4
Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro.囊性纤维化汗腺在体内和体外的β肾上腺素能反应缺陷。
J Clin Invest. 1984 Jun;73(6):1763-71. doi: 10.1172/JCI111385.
5
Effects of reserpine treatment on beta-adrenergic/adenylate cyclase modulate secretion and resynthesis by the rat submandibular gland.利血平治疗对大鼠下颌下腺β-肾上腺素能/腺苷酸环化酶调节分泌及再合成的影响。
Virchows Arch A Pathol Anat Histol. 1981;392(2):185-98. doi: 10.1007/BF00430820.
6
Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol.利血平和异丙肾上腺素长期处理后大鼠下颌下腺中糖缀合物的变化。
Histochemistry. 1988;90(4):285-8. doi: 10.1007/BF00495972.
7
Adrenoceptors and the lung: their role in health and disease.肾上腺素能受体与肺：它们在健康与疾病中的作用。
Eur J Pediatr. 1989 Jan;148(4):286-93. doi: 10.1007/BF00444116.
8
Impaired amylase release from the parotid gland of rats treated with reserpine.利血平处理的大鼠腮腺淀粉酶释放受损。
Experientia. 1979 Oct 15;35(10):1343-5. doi: 10.1007/BF01963998.