低频重复经颅磁刺激可减轻纤维肌痛疼痛。
Slow-frequency rTMS reduces fibromyalgia pain.
作者信息
Sampson Shirlene M, Rome Jeffrey D, Rummans Teresa A
机构信息
Department of Psychiatry and Psychology, W11A, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
出版信息
Pain Med. 2006 Mar-Apr;7(2):115-8. doi: 10.1111/j.1526-4637.2006.00106.x.
OBJECTIVE
Evidence suggests that fibromyalgia (FM) is a centrally mediated pain disorder. Antidepressants, including electroconvulsive therapy, provide some symptomatic relief in FM and other pain disorders. Repetitive transcranial magnetic stimulation (rTMS) is a new antidepressant treatment, which may also be useful in treating chronic pain.
DESIGN
As part of a larger study, four women with depression, FM, and borderline personality disorder received 1-Hz rTMS applied to the right dorsolateral prefrontal cortex. Subjects rated pain using an 11-point Likert scale.
RESULTS
Pretreatment pain averaged 8.2 (7-9.5) and reduced to 1.5 (0-3.5) after treatment (P < 0.009). All had improvement in pain, and two had complete resolution of pain. Only one of the four subjects had an antidepressant response.
CONCLUSIONS
These preliminary findings suggest a possible role for rTMS in treating FM.
目的
有证据表明纤维肌痛（FM）是一种中枢介导的疼痛障碍。包括电休克疗法在内的抗抑郁药可使FM及其他疼痛障碍的症状得到一定缓解。重复经颅磁刺激（rTMS）是一种新型抗抑郁治疗方法，可能对治疗慢性疼痛也有用。
设计
作为一项更大规模研究的一部分，4名患有抑郁症、FM和边缘型人格障碍的女性接受了应用于右侧背外侧前额叶皮质的1赫兹rTMS治疗。受试者使用11点李克特量表对疼痛进行评分。
结果
治疗前疼痛平均评分为8.2（7 - 9.5），治疗后降至1.5（0 - 3.5）（P < 0.009）。所有患者的疼痛均有改善，其中2名患者疼痛完全缓解。4名受试者中只有1人有抗抑郁反应。
结论
这些初步研究结果表明rTMS在治疗FM中可能发挥作用。
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