Ostertag J U, Quaedvlieg P J F, Kerckhoffs F E M J, Vermeulen A H M, Bertleff M J O E, Venema A W, van der Geer S, Krekels G A M
Department of Dermatology, University Hospital Maastricht, the Netherlands.
Br J Dermatol. 2006 May;154(5):889-95. doi: 10.1111/j.1365-2133.2005.07106.x.
Giant congenital melanocytic naevi (CMN) are often disfiguring, potentially malignant pigmented lesions present at birth. Their management is based on two main considerations: attempt to minimize the risk of malignancy and to obtain an acceptable cosmetic result. In the past various approaches have been used to treat these naevi.
To describe clinical and histopathological results after treatment of CMN in neonates with erbium:YAG (Er:YAG) laser resurfacing.
Ten children with CMN were treated with Er:YAG laser resurfacing in the first weeks of life.
Laser ablation was well tolerated by all children and immediate results were good. At a total follow-up ranging from 3 to 36 months we saw good results, with no or minimal repigmentation, in eight of 10 patients. Patients experienced minimal side-effects such as postoperative pain, bleeding and scar formation. Postoperative histopathology showed disappearance of heavily pigmented cells in the upper part of the dermis.
Er:YAG laser resurfacing is an effective method of ablating CMN, with minimal scarring and postoperative complications.
巨大先天性黑素细胞痣（CMN）通常是出生时就存在的、会造成容貌损毁且有潜在恶变可能的色素性皮损。其治疗主要基于两个主要考虑因素：尽量降低恶变风险并获得可接受的美容效果。过去曾采用多种方法治疗这些痣。
描述用铒：钇铝石榴石（Er：YAG）激光磨皮治疗新生儿CMN后的临床和组织病理学结果。
10例患有CMN的儿童在出生后的头几周接受了Er：YAG激光磨皮治疗。
所有儿童对激光消融耐受性良好，即时效果良好。在3至36个月的总随访期内，10例患者中有8例效果良好，色素沉着无或极少。患者经历的副作用极小，如术后疼痛、出血和瘢痕形成。术后组织病理学显示真皮上部色素沉着严重的细胞消失。
Er：YAG激光磨皮是一种有效消融CMN的方法，瘢痕形成和术后并发症极少。
