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双模式2940纳米铒:钇铝石榴石激光消融联合手术切除治疗中等大小先天性黑素细胞痣

A Combination of Dual-mode 2,940 nm Er:YAG Laser Ablation with Surgical Excision for Treating Medium-sized Congenital Melanocytic Nevus.

作者信息

Lim Ji Yeon, Jeong Yun, Whang Kyu Kwang

机构信息

Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.

出版信息

Ann Dermatol. 2009 May;21(2):120-4. doi: 10.5021/ad.2009.21.2.120. Epub 2009 May 31.

Abstract

BACKGROUND

There are various treatment options for congenital melanocytic nevus (CMN), including surgical excision, dermabrasions, curettage, laser treatment, chemical peels and cryosurgery. The proper choice of treatment depends on the size, location, thickness and clinical appearance of the nevi, the risk for developing melanoma, the psychological effect and the cosmetic component.

OBJECTIVE

THE PURPOSE OF THIS STUDY IS TO EVALUATE THE OUTCOME OF A COMBINATION OF SURGICAL EXCISION WITH ER: YAG laser ablation for treating CMNs.

METHODS

A total of 13 patients were included in this study. The nevus was excised as much as possible and only dermal suturing was performed, without epidermal suturing, for the primary closure. We then ablated the whole lesion, including the suture lines, by using a dual-mode 2,940 nm Er:YAG laser with three to five passes. All the lesions were followed up for 6 months and they were evaluated with respect to the healing status, infection, erythema, scarring, textural change and pigmentary change. Subject satisfaction was scored at the 16(th) week by the patients.

RESULTS

Eleven (83%) of the 13 patients were clinically rated as having a good to excellent result by the physicians' Global Assessment Scale (GAS) scores for the lesions' reduction of size, the degree of scarring and the pigmentary change with only a one stage procedure. 10 (77%) of the total 13 patients reported a good to excellent result at four months after treatment.

CONCLUSION

A combination of surgical excision with Er:YAG laser ablation as a one stage procedure is a safe, effective modality and it should be considered as one of the options for treating medium-sized CMNs.

摘要

背景

先天性黑素细胞痣(CMN)有多种治疗选择,包括手术切除、磨皮术、刮除术、激光治疗、化学剥脱术和冷冻手术。治疗方法的正确选择取决于痣的大小、位置、厚度和临床表现、发生黑色素瘤的风险、心理影响和美容因素。

目的

本研究的目的是评估手术切除联合铒:钇铝石榴石(Er:YAG)激光消融治疗CMN的效果。

方法

本研究共纳入13例患者。尽可能切除痣,一期缝合时仅进行真皮缝合,不进行表皮缝合。然后使用双模式2940nm Er:YAG激光对整个病变包括缝线部位进行三至五次照射消融。所有病变均随访6个月,评估其愈合状态、感染情况、红斑、瘢痕形成、质地变化和色素沉着变化。患者在第16周对主观满意度进行评分。

结果

13例患者中有11例(83%)经医生的整体评估量表(GAS)对病变大小缩小、瘢痕形成程度和色素沉着变化进行评分,临床评定为良好至优秀,且仅需一期手术。13例患者中有10例(77%)在治疗后4个月报告效果良好至优秀。

结论

手术切除联合Er:YAG激光消融作为一期手术是一种安全、有效的治疗方式,应被视为治疗中等大小CMN的选择之一。

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