Doherty D, Tu S, Schilmoeller K, Schilmoeller G
College of Education and Human Development, University of Maine, Orono, ME 04469-5749, USA.
Child Care Health Dev. 2006 May;32(3):333-42. doi: 10.1111/j.1365-2214.2006.00602.x.
To explore and compare the prevalence and expression of specific health-related variables in a large survey sample of persons with agenesis of the corpus callosum (ACC) and their siblings.
Caregiver surveys of individuals with ACC (n=189) and their siblings (n=189) provided data regarding diagnoses, physical features, neurological and sensory information, feeding, elimination and sleep concerns, and some behavioural features.
Compared with their siblings, individuals with ACC had more concurrent conditions and were more likely to have altered pain perception and sensitivity to touch. In addition, individuals with ACC had more sensory deficits and abnormalities as well as altered patterns of feeding/eating, elimination and sleep.
These data raise important questions for future research and suggest the need for increased vigilance by caregivers and health-care professionals of individuals with callosal disorders. Early detection and intervention may help prevent or ameliorate health problems in this population.
在一个关于胼胝体发育不全（ACC）患者及其兄弟姐妹的大型调查样本中，探索并比较特定健康相关变量的患病率和表达情况。
对ACC患者（n = 189）及其兄弟姐妹（n = 189）的照顾者进行调查，获取有关诊断、身体特征、神经和感觉信息、喂养、排泄和睡眠问题以及一些行为特征的数据。
与他们的兄弟姐妹相比，ACC患者有更多并发疾病，更有可能出现疼痛感知改变和触觉敏感性改变。此外，ACC患者有更多的感觉缺陷和异常，以及喂养/进食、排泄和睡眠模式的改变。
这些数据为未来研究提出了重要问题，并表明胼胝体疾病患者的照顾者和医疗保健专业人员需要提高警惕。早期发现和干预可能有助于预防或改善该人群的健康问题。
