Killian G, Miller L, Rhyan J, Doten H
Almquist Research Center, The Pennsylvania State University, University Park, PA 16802, USA.
Am J Reprod Immunol. 2006 May;55(5):378-84. doi: 10.1111/j.1600-0897.2006.00379.x.
Methods to limit fertility of feral swine are needed to reduce transmission of diseases and agricultural and ecosystem damage. Method of Study We evaluated a single-shot GnRH immunocontraceptive vaccine in both male and female feral swine for its effect on fertility and functional status of the reproductive tissues. Captive feral pigs were randomly assigned to receive 1000 or 2000 microg GnRH-KLH vaccine treatments or no treatment.
After 36 weeks, none of the 2000-microg-treated females and only 20% of the 1000-microg-treated females were pregnant. This corresponded to reduced serum progesterone, regressed tissues within the reproductive tract and lack of evidence for follicular development leading to ovulation. Males were less responsive to the vaccine than females, but more responsive to the lower dose of the vaccine than the higher dose.
The single-shot GnRH vaccine is effective in controlling fertility of female feral swine and may be useful for population reduction.
需要采取方法限制野猪的繁殖力，以减少疾病传播以及农业和生态系统损害。研究方法 我们评估了一种单次注射的促性腺激素释放激素（GnRH）免疫避孕疫苗对雄性和雌性野猪繁殖力及生殖组织功能状态的影响。将圈养的野猪随机分为三组，分别接受1000微克或2000微克GnRH-钥孔戚血蓝蛋白（KLH）疫苗处理或不接受处理。
36周后，接受2000微克疫苗处理的雌性野猪无一怀孕，接受1000微克疫苗处理的雌性野猪只有20%怀孕。这与血清孕酮水平降低、生殖道组织退化以及缺乏卵泡发育导致排卵的证据相符。雄性野猪对疫苗的反应不如雌性野猪，但对较低剂量疫苗的反应比对较高剂量疫苗的反应更明显。
单次注射的GnRH疫苗在控制雌性野猪繁殖力方面有效，可能有助于减少野猪数量。
