Elesber Ahmad A, Bonetti Piero O, Lerman Amir
Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Curr Treat Options Cardiovasc Med. 2006 May;8(3):213-9. doi: 10.1007/s11936-006-0014-x.
Cerebrovascular disease remains one of the most common causes of morbidity and mortality in the United States. There is strong evidence to implicate endothelial dysfunction in the initiation and progression of atherosclerosis and its complications. It is now well known that endothelial dysfunction represents a systemic syndrome involving multiple vascular beds, including the cerebral vasculature. Currently, no gold standard treatment for endothelial dysfunction exists. Nonetheless, several treatment strategies have been found to be helpful in improving endothelial function. A few of these strategies have been implicated in stroke risk reduction as well, adding another line of evidence to the relationship between endothelial function and cerebrovascular disease.
在美国，脑血管疾病仍然是发病和死亡的最常见原因之一。有充分证据表明内皮功能障碍与动脉粥样硬化及其并发症的发生和发展有关。现在众所周知，内皮功能障碍是一种涉及包括脑血管系统在内的多个血管床的全身性综合征。目前，尚无治疗内皮功能障碍的金标准疗法。尽管如此，已发现几种治疗策略有助于改善内皮功能。其中一些策略也与降低中风风险有关，为内皮功能与脑血管疾病之间的关系增添了另一系列证据。
